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- Why is synthroid taken in the morning — Synthroid (levothyroxine) 25 mg, this study showed that levothyroxine taken at bedtime significantly improved thyroid hormone levels, but quality of life parameters and plasma lipids showed no significant change as compared to morning intake. Synthroid single packs come in 50 mg and 100 mg doses and have the same prescription coverage as pills you get in a bottle.
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