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Fluoxetine may be taken with or without food. Compared to 50% on placebo.
|Fluoxetine (top), ( R )-fluoxetine (center), ( S )-fluoxetine (bottom)|
|Pronunciation||/ f l u ˈ ɒ k s ə t iː n /|
|Trade names||Prozac, Sarafem, Adofen, other|
|License data||US FDA: Fluoxetine|
|Pregnancy category||AU: C US: C (Risk not ruled out)|
|Dependence liability||Physical: Low Psychological: Low|
|Routes of administration||By mouth|
|ATC code||N06AB03 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only|
|Protein binding||94–95% |
|Metabolism||Liver (mostly CYP2D6-mediated) |
|Elimination half-life||1–3 days (acute) 4–6 days (chronic)  |
|Excretion||Urine (80%), faeces (15%)  |
Weight change should be monitored during therapy. Close monitoring of clinical worsening and behavioural changes during the 1st few mth of treatment or when there are dose changes. Upon the appearance of rash or of other possibly allergic phenomena for which an alternative etiology cannot be identified, fluoxetine should be discontinued.
Elderly patients and patients taking diuretics or who are otherwise volume-depleted may be at greater risk.
The percentage of patients experiencing convulsions in all US fluoxetine clinical trials appears to be similar to that associated with other marketed drugs effective in the treatment of MDD and . Extensively hepatic by demethylation to norfluoxetine.
A gradual reduction in the buy fosamax rather than abrupt cessation is recommended whenever possible. Nervousness, insomnia, anxiety, headache, tremor, drowsiness, dry mouth, nausea, vomiting, sweating, diarrhoea with . Do not use fluoxetine with thioridazine due to risk of QT interval prolongation and elevated thioridazine plasma levels.
Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants may add to this risk.
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These reactions have occurred with dyspnea as the only preceding symptom. Because of the long elimination half-lives of the parent drug and its major active metabolite, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment.
Discontinuation of fluoxetine should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted. Significant weight loss, especially fluoxetine 20 mg price underweight depressed or bulimic patients, may be an undesirable result of treatment with fluoxetine and primatene non-prescription asthma inhaler back after 7 years.
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In patients with diabetes, hypoglycemia has occurred during therapy with fluoxetine, and hyperglycemia has developed following discontinuation of the drug. Special Precautions for Fluoxetine 60mg: A major depressive episode may be the initial presentation of Bipolar Disorder.
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Consider discontinuing fluoxetine and obtaining a cardiac evaluation if patients develop signs or symptoms consistent with ventricular arrhythmia and .
Side Effects of Fluoxetine 20mg: Nervousness, insomnia, anxiety, headache, tremor, drowsiness, dry mouth, nausea, vomiting, sweating, diarrhoea.
- Upon the appearance of rash or of other possibly allergic phenomena for which an alternative etiology cannot be identified, fluoxetine should be discontinued
- In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behavior
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Fluoxetine should be introduced with care in patients with a history of seizures. Mechanism of Action of Fluoxetine 20mg: Although these reactions are rare, they may be serious, involving the lung, kidney, or liver.
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|In many cases||In patients with diabetes|
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Patients should be monitored for emergence of serotonin syndrome. Two-fold increase in plasma levels of other antidepressants when combined with fluoxetine. Sure, most of the time we wear our women's dress shoes with a dress, but more often than not we also wear them with our tailored trousers, business suits and jeans.
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