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Levothyroxine
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa682461
Pregnancy categoryUS: A (No risk in human studies)
Routes of administrationby mouth, intravenous
ATC codeH03AA01 ( WHO )
Legal status
Legal statusUS: ℞-only
Pharmacokinetic data
Bioavailability40-80% [1]
Metabolismmainly in liver, kidneys, brain and muscles
Elimination half-lifeca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days)
Excretionfeces and urine

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Actions of particular beta-adrenergic antagonists may be impaired when a hypothyroid patient is converted to the euthyroid state. Drug or Drug Class Phenobarbital Rifampin Phenobarbital has been shown to reduce the response to thyroxine.

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Atrial arrhythmias can occur in elderly patients. Undertreatment may have deleterious effects on intellectual development and linear growth.

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Serum digitalis glycoside levels may decrease when a hypothyroid patient becomes euthyroid, related website an increase in the dose of digitalis glycosides. Atrial arrhythmias can occur in elderly patients. Toxic effects may include increased risk of cardiac arrhythmias and central nervous system stimulation.

Acquired Hypothyroidism in Pediatric Patients Closely monitor patients to avoid undertreatment and overtreatment.

Larger doses may result in serious or even life-threatening events, especially when used in combination with certain other drugs used to reduce appetite. Ask questions if you are uncertain. It may be necessary for you to take this medicine for the rest of your life.

SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland thyroiditis with .

Some items may interact with your medicine. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland thyroiditis.

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